The realization that the headaches of patients with migraine who had ‘botulinum toxin’ (botox) were applied to eliminate facial wrinkles, paved the way for the use of botox in the treatment of migraine. Studies have shown that the effect of 15 or 15 per month for more than 3 months is thought to be due to Botox preventing inflammatory pain by inhibiting the release of certain neurotransmitters in nerve endings.

Botox in the treatment of migraine; It is applied to the forehead, temples, nape and neck area.
Botox, which is applied only on the face for cosmetic purposes, is applied by injecting botulinum toxin subcutaneously to certain points in the forehead, temples, nape and neck regions, unlike this in migraine treatment. In most cases, the effect of the applications will last for about 3-4 months, so it needs to be repeated for the continuation of the treatment.

This showed that botox application is effective in the treatment of chronic migraine, which is defined as headache with migraine character for more days.